Epithalon
Epithalon is the most studied longevity peptide in existence, with over 40 years of research behind it. This four-amino-acid peptide was discovered in the pineal gland and has a unique ability to activate telomerase — the enzyme responsible for rebuilding the ends of your chromosomes that shorten with every cell division. By lengthening telomeres, Epithalon effectively reverses one of the core biological mechanisms of aging. It also regulates melatonin production, supports immune function, and has been shown in long-term studies to meaningfully extend both healthspan and lifespan.
Key Benefits
- Activates telomerase to lengthen telomeres — directly reversing cellular aging
- Restores youthful melatonin production for deeper sleep and circadian rhythm regulation
- Strengthens immune function and reduces age-related immune decline
- Powerful antioxidant effects — reduces oxidative damage across all tissues
- Shown in human studies to reduce mortality and extend lifespan
- Reduces risk of age-related diseases including cancer, cardiovascular disease, and neurodegeneration
- Improves skin quality, energy, and overall vitality
- Resets the biological clock at the cellular level
If you're serious about longevity, Epithalon is non-negotiable. No other peptide has this depth of evidence for directly targeting the biology of aging. ≥99% purity, third-party HPLC verified.
| Sequence | Ala-Glu-Asp-Gly |
| Molecular Weight | 390.35 g/mol |
| Molecular Formula | C14H22N4O9 |
| CAS Number | 307297-39-8 |
| Target / Receptor | Telomerase activator; pineal gland analogue |
| Physical Form | Lyophilized Powder |
| Storage | -20°C, protect from light |
Reconstitution Guide
For laboratory research use only. Follow aseptic technique throughout.
Equilibrate Temperature
Remove the vial from the freezer and allow it to reach room temperature before opening. This prevents condensation from entering the vial.
Wait 15–20 minutes at room temperature
Add Bacteriostatic Water
Reconstitute in bacteriostatic water. Highly stable post-reconstitution. Refrigerate at 4°C after opening.
Use a sterile 1 mL insulin syringe for precision
Dissolve Gently
Gently swirl or roll the vial between your palms until the peptide is fully dissolved. Do not shake vigorously or vortex — this can cause aggregation and degrade the compound.
Solution should appear clear to slightly opalescent
Aliquot & Store
Transfer reconstituted solution into sterile single-use vials to avoid repeated needle punctures. Store working aliquots at 4°C (use within 28 days) or freeze at -20°C for long-term storage.
Avoid more than 3 freeze-thaw cycles
Concentration Reference (per 1 mg peptide)
| Bacteriostatic Water | Concentration | Per mL Dose |
|---|---|---|
| 1 mL | 1 mg/mL | 1,000 mcg/mL |
| 2 mL | 0.5 mg/mL | 500 mcg/mL |
| 5 mL | 0.2 mg/mL | 200 mcg/mL |
| 10 mL | 0.1 mg/mL | 100 mcg/mL |
Storage Conditions
-20°C, protect from light
